Andres Luna de San Pedro was born on september 9, 1887 in the French capital Paris. His parents were Paz Pardo de Tavera, sister of Trinidad Pardo de Tavera and painter Juan Luna. Andres grew up in Paris until he was six years old and his father on 22 september 1892 shot dead his mother and mother-in-law. He was acquitted by a French court in early February, because it concerned a crime of passion and left with Andres the following week to Spain. After spending six months in Barcelona and Paris they travelled by boat along with Andres ' uncle Antonio Luna to the Philippines, where they arrived in Manila on May 24, 1894.
After returning to the Philippines from 1920 to 1924 he was chief architect of the city of Manila. The designs of Luna de San Pedro were either modernist or revivalistisch of style. Many of his modernist buildings are lost in the Second World War . One such example was The Crystal Arcade, a building with shops and offices. Examples of buildings of his hand in the revivalistische style are the Legarda Elementary School (1922), the home of Alfonso Zobel Roxas Street and Padre Faura Street, to the Paul Church to the Vicente San Marcelino Street (1930) and the House of Rafael Fernandez to Arlegui Street, that after 1986 was used as official residence by president Corazon Aquino.
Luna de San Pedro gave in addition to his work as an architect also taught at the University and was also president of the Philippine Institute of Architects. In 1949, he was awarded the Gold Medal of Merit as the first architect of the Philippine Institute of Architects (PIA).
Luna died in 1952 at the age of 64. He was married to Grace v. Mcrae.