He graduated from the Government College in Lahore in 1911 and then studied at King's College in London. After his return to India he was lawyer in Sialkot and Lahore, and he taught Law at the Law College in Lahore.
Zafrullah Khan was an active member of the All India Muslim League. In 1926 he was elected for the Parliament of Punjab. He was the first Foreign Minister of Pakistan in1947 and continued that over seven years; He also represented the newly independent Pakistan in the General Assembly of the United Nations as head of the Pakistani delegation. From 1948 to 1954 he was a member on behalf of Pakistan in the United Nations Security Council. He was President of the 17th General Assembly of the United Nations from 1962 to 1963.
Muhammad Zafrullah Khan was an active ahmadi and was amir (President) of the local ahmadiyya community of Lahore from 1919 to 1935. He was a confidant of Mirza Bashiruddin Mahmood Ahmad, the second Caliph of the Ahmadiyya Muslim community, and regularly acted as his Secretary during the Shura.
Muhammad Zafrullah Khan wrote and translated many works on islam and the Ahmadiyya Muslim community. Most of his works are still available .
- Message of Islam
- The Excellent Exemplar-Muhammad-The Messenger of Allah
- Nature of Quranic Teachings
- Re-Institution of Khilafat
- Islamic Concept of the State
- Punishment of Apostacy in Islam
- The Contribution of Islam to the Solution of World Problems
- Muhammad: Seal of The Prophets
- The Renaissance of Islam Ahmadiyyat